Our literature study (Chevalier et al. 2010) has identified several deep saline aquifers in the Swiss Molasse Basin, which may potentially be used as reservoirs to store industrial CO2. One of the aquifers considered as a possible injection target is the Trigonodus Dolomite of the Upper Muschelkalk formation. To further evaluate its storage capacity, injectivity and long-term isolation performance, predictive numerical simulations are carried out, constrained by experimental and observational data.